Beilstein J. Org. Chem.2011,7, 759–766, doi:10.3762/bjoc.7.86
; organofluorinebuildingblocks; α-(trifluoromethyl)-β-lactam; Introduction
β-Lactams (azetidin-2-ones) have played a prominent role in medicinal chemistry and many structural variants have been prepared and elaborated [1]. Similarly, the CF3 group is an ubiquitous substituent in pharmaceutical research, where
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Graphical Abstract
Figure 1:
Enantiomers of α-(trifluoromethyl)-β-lactam (1).